Biomagnetic Signals Recorded During Transcranial Magnetic Stimulation (TMS)-Evoked Peripheral Muscular Activity

SOURCE: Biomedizinische Technik. 67(5):333-344, 2022 Oct 26.

AUTHORS: Iwata GZ; Hu Y; Wickenbrock A; Sander T; Muthuraman M; Chirumamilla VC; Groppa S; Liu Q; Budker D

ABSTRACT: Transcranial magnetic stimulation (TMS) has widespread clinical applications from diagnosis to treatment. We combined TMS with non-contact magnetic detection of TMS-evoked muscle activity in peripheral limbs to explore a new diagnostic modality that enhances the utility of TMS as a clinical tool by leveraging technological advances in magnetometry. We recorded measurements in a regular hospital room using an array of optically pumped magnetometers (OPMs) inside a portable shield that encloses only the forearm and hand of the subject. We present
magnetomyograms (MMG)s of TMS-evoked movement in a human hand, together with a simultaneous surface electromyograph (EMG) data. The biomagnetic signals recorded in the MMG provides detailed spatial and temporal information that is complementary to that of the electric signal channels. Moreover, we identify features in the magnetic recording beyond that of the EMG. This system demonstrates the value of biomagnetic signals in TMS-based clinical approaches and widens its availability and practical potential.