Title:
Differential Effects of HRAS Mutation on LTP-Like Activity Induced by
Different Protocols of Repetitive Transcranial Magnetic Stimulation.
Authors:
Dileone M; Ranieri F; Florio L; Capone F; Musumeci G; Leoni C;
Mordillo-Mateos L; Tartaglia M; Zampino G; Di Lazzaro V.
Institution Dileone,Michele. Hospital Nacional de Paraplejicos, SESCAM, Toledo, Spain; Department of Neurosciences, San Bortolo Hospital, Vicenza, Italy; CINAC, HM Puerta del Sur, Hospitales de Madrid, 28938 Mostoles, Spain. Electronic address: dileone.michele@ulssvicenza.it.
Ranieri,Federico. Institute of Neurology, Campus Biomedico University,
Rome, Italy; Fondazione Alberto Sordi – Research Institute for Ageing,
Rome, Italy. Florio,Lucia. Institute of Neurology, Campus Biomedico University, Rome, Italy; Fondazione Alberto Sordi – Research Institute for Ageing, Rome, Italy. Capone,Fioravante. Institute of Neurology, Campus Biomedico University, Rome, Italy; Fondazione Alberto Sordi – Research Institute for Ageing, Rome, Italy. Musumeci,Gabriella. Institute of Neurology, Campus Biomedico University, Rome, Italy; Fondazione Alberto Sordi – Research Institute for Ageing, Rome, Italy. Leoni,Chiara. Servizio di Epidemiologia e Clinica dei Difetti CongenitiIstituto di Clinica Pediatrica, Catholic University, Rome, Italy. Mordillo-Mateos,Laura. Department of Neurosciences, San Bortolo Hospital, Vicenza, Italy. Tartaglia,Marco. Dipartimento di Ematologia, Oncologia e Medicina Molecolare, Istituto Superiore di Sanita, Rome, Italy. Zampino,Giuseppe. Servizio di Epidemiologia e Clinica dei Difetti Congeniti Istituto di Clinica Pediatrica, Catholic University, Rome, Italy. Di Lazzaro,Vincenzo. Institute of Neurology, Campus Biomedico University, Rome, Italy; Fondazione Alberto Sordi – Research Institute for Ageing, Rome, Italy.
Title:
Differential Effects of HRAS Mutation on LTP-Like Activity Induced by
Different Protocols of Repetitive Transcranial Magnetic Stimulation.
Source:
Brain Stimulation. 9(1):33-8, 2016 Jan-Feb.
BACKGROUND:
Costello syndrome (CS) is a rare congenital disorder due to a
G12S amino acid substitution in HRAS protoncogene. Previous studies have shown that Paired Associative Stimulation (PAS), a repetitive brain
stimulation protocol inducing motor cortex plasticity by coupling peripheral nerve stimulation with brain stimulation, leads to an extremely
pronounced motor cortex excitability increase in CS patients. Intermittent
Theta Burst Stimulation (iTBS) represents a protocol able to induce motor
cortex plasticity by trains of stimuli at 50Hz. In healthy subjects PAS
and iTBS produce similar after-effects in motor cortex excitability.
Experimental models showed that HRAS-dependent signalling pathways
differently affect LTP induced by different patterns of repetitive synaptic stimulation.
OBJECTIVE:
We aimed to compare iTBS-induced after-effects on motor cortex excitability with those produced by PAS in CS patients and to
observe whether HRAS mutation differentially affects two different forms
of neuromodulation protocols.
METHODS:
We evaluated in vivo after-effects induced by PAS and iTBS applied over the right motor cortex in 4 CS patients and in 21 healthy age-matched controls.
RESULTS:
Our findings confirmed HRAS-dependent extremely pronounced
PAS-induced after-effects and showed for the first time that iTBS induces
no change in MEP amplitude in CS patients whereas both protocols lead to
an increase of about 50% in controls.
CONCLUSIONS:
CS patients are characterized by an impairment of iTBS-related LTP-like phenomena besides enhanced PAS-induced after-effects, suggesting that HRAS-dependent signalling pathways have a differential influence on PAS- and iTBS-induced plasticity in humans.
Copyright:
2015 Elsevier Inc. All rights reserved.
Publication Type:
Journal Article. Research Support, Non-U.S. Gov’t.
