Ranieri F; Ferraccioli M; StampanoniBassi M; Musumeci G; Di Lazzaro V; Gainotti G; Marra C. Institution Ranieri,F. Department of Neurology, Campus Bio-Medico University, R ome, Italy. Ferraccioli,M. Institute of Neurology and Center for Neuro psychological Research of the PoliclinicoGemelli, Catholic University of Ro me, Italy. StampanoniBassi,M. Institute of Neurology and Center for Neuropsychological Research of the PoliclinicoGemelli, Catholic University of Rome, Italy. Musumeci,G. Department of Neurology, Campus Bio-Medico University, Rome, Italy. Di Lazzaro,V. Department of Neurology, Campus Bio-Medico Universit y, Rome, Italy. Gainotti,G. Institute of Neurology and Center for Neuropsychological Research of the PoliclinicoGemelli, Catholic University of Ro me, Italy; IRCCS Fondazione Santa Lucia, Department of Clinical and Behavioral Neurology, Rome, Italy. Electronic address: email@example.com .it. Marra,C. Institute of Neurology and Center for Neuropsycho logical Research of the PoliclinicoGemelli, Catholic University of Rome, It aly.
Familiarity for famous faces and names is not equally subtended by the right and left temporal poles. Evidence from an rTMS study.
Neurobiology of Learning & Memory. 125:15-23, 2015 Nov .
The aims of the present experiment was to investigate: (a) if transient disruption of neural activity in the right (RTP) or left temp oral pole (LTP) can interfere with the development of a familiarity feeling to the presentation of faces/written names of famous/unknown people; and (b) if this interference specifically affects the familiarity for faces aft er inhibition of the RTP and for names after inhibition of the LTP. Twenty healthy volunteers took part in the study. Repetitive transcranial magnetic stimulation (rTMS) was administered online; it disrupted the neural activity of the right or left TP in concomitance with the presentation of each face and name whose familiarity had to be assessed. Furthermore, in a control group, each participant was submitted to a single experimental session in which rTMS was delivered to the vertex in association with the presentation of faces and written names. Since previous rTMS studies have shown that the temporary inactivati on of the right and left TP influences the response latencies, but not the number of correct responses, in this study we took into account both the number of correct responses obtained in different experimental conditions and t he corresponding response latencies. A three-way factorial ANOVA carried out on the Response Scores showed only a general effect of the Type of Stimuli, due to better performances on names than on faces. This greater familiarity of names is consistent with previous data report ed in the literature. In the three-way factorial ANOVA carried out on the Latency Scores, post-hoc analyses showed an increased latency of responses to faces after right stimulation in Latency Total, Latency on Correct responses and Latency on Unfamiliar faces. None of these results were obtained in the control group. These data suggest that rTMS at the level of the RTP preferentially affects the development of familiarity feelings to the presentation of faces of famous people.
Copyright © ; 2015 Elsevier Inc. All rights reserved. Publication Type Journal Article. Randomized Controlled Trial