Left Prefrontal Repetitive Transcranial Magnetic Stimulation in a Logopenic Variant of Primary Progressive Aphasia: A Case Report
Bereau M; Magnin E; Nicolier M; Berthet L; Dariel E; Ferreira S; Sylvestre G; Monnin J; Chopard G; Bouladour H; Vandel P; Haffen E.
European Neurology. 76(1-2):12-8, 2016.
BACKGROUND / AIMS
High frequency repetitive transcranial magnetic stimulation (hf-rTMS) improves language skills in Alzheimer’s disease (AD). We report the use of hf-rTMS in a patient with logopenic primary progressive aphasia (LPPA) due to AD.
hf-rTMS was applied to the left dorsolateral prefrontal cortex of a LPPA patient. Cerebral perfusion, neuropsychological and linguistic performances were evaluated before and 1 month after hf-rTMS.
The tolerance was good. Improvements on linguistic (fluency, naming, lesser paraphasia) and cognitive skills (Mini Mental State Examination, verbal memory free recall, speed processing) and cerebral perfusion were observed.
hf-rTMS can be used in LPPA patients. A procognitive effect persisting several weeks after stimulation in LPPA patients was suggested and should therefore be evaluated in a clinical trial as an adjunctive therapeutic tool.