Neuromodulation of Cognition in Parkinson’s Disease [Review]

SOURCE: Progress in Brain Research. 269(1):435-455, 2022.

AUTHORS: Cole RC; Okine DN; Yeager BE; Narayanan NS

ABSTRACT: Neuromodulation is a widely used treatment for motor symptoms of
Parkinson’s disease (PD). It can be a highly effective treatment as a result of knowledge of circuit dysfunction associated with motor symptoms in PD. However, the mechanisms underlying cognitive symptoms of PD are less well-known, and the effects of neuromodulation on these symptoms are less consistent. Nonetheless, neuromodulation provides a unique opportunity to modulate motor and cognitive circuits while minimizing off-target side effects. We review the modalities of neuromodulation used in PD and the potential implications for cognitive symptoms. There have been some encouraging findings with both invasive and noninvasive modalities of neuromodulation, and there are promising advances being made in the field of therapeutic neuromodulation. Substantial work is needed to determine which modulation targets are most effective for the different types of cognitive deficits of PD.