Neurostimulation as an Intervention for treatment resistant depress on: From research on mechanisms towards targeted neurocognitive strategies.


De Raedt R; Vanderhasselt MA; Baeken C. Institution De Raedt,Rudi. Department of Experimental Clinical and Health Psycholog y, Ghent University, Ghent, Belgium. Electronic address: . Vanderhasselt,Marie-Anne. Department of Experimental Clinical and Hea lth Psychology, Ghent University, Ghent, Belgium. Baeken,Chris. Department of Psychiatry and Medical Psychology and Ghent Experimental Psychiatry (GHEP) Lab, Ghent University, Ghent, Belgi um; Department of Psychiatry, University Hospital UZBrussel, Brussels , Belgium.


Neurostimulation as an intervention for treatment resistant depress on: From research on mechanisms towards targeted neurocognitive strategies. [Review]

Source: Clinical Psychology Review. 41:61-9, 2015 Nov.

Abstract: Despite the fact that several interventions for major depression h ave proven efficacy, a substantial number of patients are or become trea tment resistant to various forms of pharmacotherapy and psychothera py. Biological interventions that directly target brain activity such as electroconvulsive therapy are used to treat these patients, but s ome of these interventions are unlikely to be easily accepted because of their more invasive nature or side-effects. The efficacy of non-invasiv e neurostimulation with a favorable side effect profile, such as repetitive Transcranial Magnetic Stimulation, could not be sufficie ntly demonstrated for treatment resistant depressed patients (TRD). We argue that research on the working mechanisms of these neurostimulation techniques is necessary to develop more efficient treatment protocols. After an ov erview of current neurostimulation approaches to treatment resistance and t he introduction of a neurobiological and a cognitive framewor k of depression, we provide an integrative review of research on both the neuro biological and cognitive working mechanisms of neurostimulation in TRD, with a specific emphasis on the work of our lab. Thereafter, we desc ribe our own studies and studies from other labs on new neurocognitive i nterventions. Finally we discuss how all this knowledge can be used to fu rther develop new strategies to deal with treatment resistance, in combining neurostimulation and cognitive interventions.

Copyright a9; 2014 Elsevier Ltd. All rights reserved.

Publication Type Journal Article. Research Support, Non-U.S. Gov’t. Review.