Rehabilitation Effect of rTMS Combined with Cognitive Training on Cognitive Impairment After Traumatic Brain Injury


American Journal of Translational Research. 13(10) (pp 11711-11717), 2021. Date of Publication: 2021.

Zhou L.; Huang X.; Li H.; Guo R.; Wang J.; Zhang Y.; Lu Z.

To investigate the rehabilitation effects of repetitive transcranial magnetic stimulation (rTMS) combined with cognitive training on cognitive impairment in patients with traumatic brain injury (TBI) by using multimodal magnetic resonance imaging.

Clinical data of 166 patients with cognitive impairment after TBI were retrospectively analyzed. The patients were assigned into an observation group and a control group according to different treatment methods, with 83 cases in each group. The observation group was given rTMS + cognitive training, and the control group was given cognitive training only. The changes in GCS score, the Cho/Cr, Cho/NAA and NAA/Cr ratios examined by MRSI, the score of cognitive impairment, the grading of cognitive impairment, and the changes in modified Barthel index were observed and compared between the two groups.

The GCS score, and the ratios of Cho/Cr, Cho/NAA and NAA/Cr after treatment were better than those before treatment in both groups and were lower in the observation group compared with the control group (all P<0.05). The score and grading of cognitive impairment as well as modified Barthel index after treatment were all significantly better in the observation group than in the control group (all P<0.05).

rTMS can improve the rehabilitation effect on cognitive impairment in patients after TBI and is recommended for clinical use.