Repetitive Transcranial Magnetic Stimulation (rTMS) as Therapy in an Infant With Epilepsia Partialis Continua

Source: Epilepsy and Behavior Reports. 18 (no pagination), 2022. Article Number:

Date of Publication: January 2022.

Authors: Chang D.; Singhal N.S.; Tarapore P.E.; Auguste K.I.

INTRODUCTION: We present a case of a 10-month-old girl undergoing repetitive TMS (rTMS) for the treatment of drug-resistant epilepsy. Case report: A 10-month-old girl, later diagnosed with pathogenic POLG1 mutations, presented to our institution with chronic progressive EPC (epilepsia partialis continua) manifesting as a frequent, left-sided, synchronous continuous jerking of the arms and legs. The seizures were drug-resistant to multiple antiseizure medications and epilepsy surgery, responding only to continuous anesthesia. rTMS therapy was attempted to
interrupt seizures.

RESULT(S): rTMS therapy, using an activating protocol to introduce a temporary lesion effect, was used to interrupt persistent, ongoing seizures.

CONCLUSION(S): rTMS can be safely used to abort seizures in patients as young as 10 months old