Title:
The Efficacy of Daily Prefrontal Repetitive Transcranial Magnetic Stimulation (rTMS) for Burning Mouth Syndrome (BMS): A
Randomized Controlled Single-blind Study.
Autors: Umezaki Y; Badran BW; DeVries WH; Moss J; Gonzales T; George MS. Brain Stimulation. 9(2):234-42, 2016 Mar-Apr.
[Journal Article. Randomized Controlled Trial]
UI: 26597930
BACKGROUND: Burning mouth syndrome (BMS) is a burning oral sensation without any corresponding abnormal findings. In some
cases, BMS is refractory to pharmacologic treatments. Repetitive transcranial magnetic stimulation (rTMS) over left prefrontal cortex
induces analgesic effect in both acute and chronic pain. However, its effect for BMS has not been evaluated.
OBJECTIVE: The aim of this randomized, controlled, single-blind study was to assess the efficacy of prefrontal rTMS for BMS.
METHOD: Twenty patients with BMS were recruited and randomized to receive 30,000 pulses in total at 10 Hz TMS (n = 12) or sham
TMS (n = 8). We assessed the change of BMS pain condition, functional status and mood until 2 months after the beginning of treatment.
RESULTS: In the real group, the BMS pain intensity decreased 67%, and 75% of the patients reported >50% pain decrease on final
assessment compared to baseline, without heavy side effects. There was significant pain reduction in subjects in the real group
immediately after 1 week of treatment, whereas there was none in those in the sham group. Similar tendency was confirmed in change
of functional status. Mood and the affective aspect of pain were not changed in this study.
CONCLUSION: BMS pain was significantly improved with 2 weeks of treatment of high frequency rTMS over left DLPFC compared to
sham stimulation. Further study is needed to refine and improve TMS as a potential treatment of BMS.
Copyright © 2016 Elsevier Inc. All rights reserved.
Institutions:
Umezaki, Yojiro. Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, 67 President Street, Charleston, SC
29425, USA. Electronic address: umezaki@yahoo.com. Badran, Bashar W. Brain Stimulation Laboratory, Department of Psychiatry, Medical
University of South Carolina, 67 President Street, Charleston, SC 29425, USA.
DeVries, William H. Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, 67 President Street, Charleston,SC 29425, USA.
Moss, Jkeonye. Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, 67 President Street, Charleston, SC
29425, USA.
Gonzales, Theresa. Division of Oral Pathology, College of Dental Medicine, Medical University of South Carolina, 173 Ashley Avenue, Charleston,
SC 29425, USA.
George, Mark S. Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, 67 President Street, Charleston, SC
29425, USA; Ralph H. Johnson VA Medical Center, 109 Bee Street, Charleston, SC 29401, USA.
