The Potential of Causal Approaches in Creativity Using Ultrasonic Brain Stimulation.

SOURCE: Current Clinical Neurology. (pp 235-253), 2023.


AUTHOR: Crone J.S.

ABSTRACT: Creativity is a crucial element regarding the adaption of many animals to their environment. However, the exact neurobiological underpinnings of creativity are elusive. However, recent research provides more and more evidence that creativity is based on an optimal balance of flexibility and stability of brain network interaction. One theory is that there exists a dopamine-dependent balance between distinct brain regions modulating cognitive focus and flexibility. An imbalance between these areas may have significant effects on creativity as has been demonstrated in patients with Parkinson’s disease, for example, who have shown changes in creativity. To further understand these relationships, it is essential to implement causative approaches to validate neurobiological-based theories. However, the current established approaches lack the ability to specifically target mechanisms that are the key players in creativity. A novel brain stimulation method, low-intensity focused ultrasound, may be a promising technique to overcome these shortcomings and provide unique insights into the neuronal mechanisms underlying creativity and its alterations in neurodegenerative diseases.