TITLE
The Predictive Value of Motor-Evoked Potentials and the Silent Period on Patient Outcome after Acute Cerebral Infarction
AUTHORS
Zhang X; Ji W; Li L; Yu C; Wang W; Liu S; Gao C; Qiu L; Tong X; Wang J; Wu J. Institution Zhang, Xueqing. Department of Electrophysiology, Tianjin Huanhu Hospital, Tianjin, China. Ji, Wenzhen. Department of Electrophysiology, Tianjin Huanhu Hospital, Tianjin, China. Li, Lancui. Department of Medical Insurance, Tianjin Huanhu Hospital, Tianjin, China. Yu, Changshen. Department of Neurology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China. Wang, Wanjun. Department of Neurology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China. Liu, Shoufeng. Department of Neurology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China. Gao, Chunlin. Department of Neurology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China. Qiu, Lina. Department of Neurology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China. Tong, Xiaoguang. Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China. Wang, Jinhuan. Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China. Wu, Jialing. Department of Neurology, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebrovascular and Neurodegenerative Diseases, Tianjin, China.
ELECTRONIC ADDRESS
wywjl2009@hotmail.com
SOURCE
Journal of Stroke & Cerebrovascular Diseases. 25(7):1713-20, 2016 Jul.
BACKGROUND
The predictive value of neurophysiologic assessment on patients’ outcome after acute cerebral infarction is poorly understood. The aim of this study was to investigate the prognostic value of motor-evoked potentials (MEPs) and the silent period (SP) on clinical outcome.
METHODS
A total of 202 patients with acute cerebral infarction were prospectively recruited. MEP and SP were recorded from the abductor pollicis brevis of the affected side within 10 days after stroke onset. Patient outcome was measured as the dependency rate.
RESULTS
Cortical MEP was induced in 78 patients whereas it was absent in 82 patients. The initial NIHSS (National Institutes of Health Stroke Scale) score was significantly lower in patients with MEP than in those without MEP (P<.001). Regression analysis demonstrated that a left-sided lesion (OR=.391, 95% CI .178-.858, P=.019), NIHSS at admission (OR=.826, 95% CI .744-.917, P<.001), and presence of MEP (OR=3.918, 95% CI 1.770-8.672, P<.001) were independent predictors of outcome 3 months after stroke. Among patients with MEP, only the contralateral cortical SP value was significantly shorter in the good outcome subgroup (t=2.541, P=.013). Receiver operating characteristic curve analysis demonstrated that SP was able to predict patients at higher risk of unfavorable outcome 3 months after stroke onset (area under the curve .721, 95% CI .58-.86, P=.008).
CONCLUSIONS
These data suggested that MEP and SP were useful tools to predict patients’ acute outcomes following cerebral infarction.
Copyright © 2016 National Stroke Association. Published by Elsevier Inc. All rights reserved. Publication Type Journal Article.
